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There was no link between mothers who smoked less than 20 cigarettes daily in 1968 and lung function in their middle aged children, nor was there a link to fathers who smoked any amount

We present clinical strategies for adverse event mitigation, monitoring recommendations, contraindications, and practical considerations for treatment discontinuation or switching

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The same study found the largest declines in lung function among dual users, with FEV1 (% predicted) falling by 18.5% and the FEV1/FVC ratio falling by 21.42% compared with non-users